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targeted protein degradation

topic1 events
papersSEP 10 04:00 UTC

ProMeta: few-shot learning predicts PROTAC degradation across E3 ligases

Researchers introduce ProMeta, a few-shot machine learning framework that forecasts how effectively PROTAC molecules degrade target proteins across different E3 ligases. PROTACs are bifunctional compounds that hijack the ubiquitin-proteasome system to eliminate disease-linked proteins long considered out of reach for conventional drugs. The method targets the scarcity of labeled data that has limited prior computational predictors for targeted degradation.

machine-learning/drug-discovery/few-shot-learning/biotech